GW-501516 also referred to as Cardarine, is a favorite compound that has been first developed in the early 1990s.
Its principal purpose is to stop the creation of tumors in organs such as the prostate, colon and breast tissue.
Although it was designed for a very different purpose, the bodybuilding community began noticing it as a unique and potentially powerful SARM (Selective Androgen Receptor Modulator).
That’s because it’s the power to burn fat, boost endurance and reduce the amount of time that bodybuilders need to recover.
The best part is that GW-501516 is stated to not have any side effects.
If this is true then it’s the best thing since sliced bread for the bodybuilding community. But is it all that it’s cracked out to be? Let us find out.
The movie below will clarify Cardarine in 1 minute!
What’s GW501516?
Pharmaceutical giant GlaxoSmithKline developed GW501516 together with the aim to leverage its advantages for the treatment of blood vessels, heart, and diabetes.
But, research on this SARM stopped during stage 2 because the animals being tested started growing cancer.
The same results have not been observed in humans however, meaning that it’s probably only harmful to animals.
In any case, it might take much longer because of its substance to start showing a cancer risk if it were to be tested for that impact on humans.
How was Cardarine discovered, you inquire?
Well, the research community has ever grappled with trying to obtain the right remedy for lifestyle disorders such as inflammation, heart disease, and diabetes.
At a certain point, scientists were searching for a chemical that would make it possible to increase physical endurance whilst accelerating the body’s fat-burning capability. That is when they stumbled upon the PPAR-delta pathway.
They found that by activating this pathway, they could immediately improve endurance, stimulate muscle growth, burn fat and increase energy while decreasing blood lipids.
Cardarine is one of the few compounds that have the capability to bind itself into the PPAR-delta pathway.
It’s intriguing to note that the Majority of the PPAR-delta is found in the muscles, therefore activating it obviously leads to:
- Increased muscle growth
- Heart wellness
- Metabolism
- Reduced inflammation
Based on these facts we can conclude that GW501516 is a promising chemical.
IS CARDARINE CONSIDERED A SARM?
No, Cardarine is NOT a SARM.
First of all, selective androgen receptor modulators (SARMs) are compounds which act on androgen receptors. All these androgen receptors are situated in bone and muscle cells in order to boost muscle mass.
SARMs such as LGD4033 and RAD140 are created with the intention to replicate the action of testosterone.
Cardarine is a PPAR-delta pathway activator. This implies that it does not target androgen receptors directly.
CARDARINE BENEFITS
Helps Burn Fat
PPAR-delta has the ability to trigger a high number of fat-burning enzymes.
In fact, personal research was conducted to corroborate these claims and found that Cardarine gets the capability to reduce fatty acids, triglycerides and VLDL proteins.
These results were based on a double-blind, randomized and controlled trial study involving 13 men who suffered from bad cholesterol and excess belly fat.
The subjects were given a minimal dose of just 2.5 milligrams per day over a span of 6 months.
In yet another study with 12 inactive men, the participants were given 5 to 10 mg of Cardarine per day for 12 weeks.
The results show that Cardarine managed to dramatically reduce their levels of HDL cholesterol, triglycerides, and APOB.
Helps with Muscle Growth and Boosts Stamina
Since Cardarine can trigger PPAR-delta pathways, in addition, it can boost endurance. One study showed that the chemical might boost muscle fibers associated with peak physical performance.
Protects the Brain
One animal study showed that Cardarine can help maintain normal blood flow into the brain. This protects brain vessels from oxidative damage and pressure.
PPAR activators are proven to improve the development of neural cells. PPAR-delta pathways can also help us achieve that outcome.
But when tested on rat brain cells, Cardarine was shown to have both pro and anti-inflammatory effects.
GW501516 increased the activity of inflammatory cells such as IL-6 while decreasing others such as TNF-alpha. So there’s no telling yet if Cardarine is good or bad for the brain.
Helps with Fat
In a different double-blind randomized and controlled trial study with 6 obese volunteers, Cardarine was able to reverse symptoms associated with metabolic syndrome and all without causing any adverse side effects.
The participants were given 2.5 to 10 milligrams of Cardarine per day for 2 weeks and showed decreased liver cholesterol, insulin, and blood glucose levels in just 2 weeks.
As if which wasn’t enough, Cardarine traveled throughout the PPAR-delta pathways to help stop the effects of inflammatory chemicals.
Thus, it was concluded that Cardarine might be of aid in handling obesity-induced insulin resistance in addition to chronic inflammation.
That is because obese insulin-resistant patients usually carry about belly fat that exposes them to higher inflammatory cytokines compared to healthy men and women that have more PPAR-delta.
Another study conducted on obese monkeys suggests that Cardarine might help reduce the risk of cardiovascular disease by lowering the occurrence of HDL cholesterol, LDL cholesterol, triglycerides, and insulin.
In research performed using mice, GW501516 was demonstrated to protect against the overproduction of glucose by the liver, while increasing insulin sensitivity. If the very same results can be achieved with individual subjects, subsequently Cardarine might be a fitting candidate for an effective treatment for Type 2 diabetes and obesity.
The mice even showed improvement in muscle fiber development, which might help prevent obesity without the need for physical exercise. The chemical may also help prevent weight gain that is brought on by lifestyle and diet by accelerating fat burning.
Protects Heart and Blood Vessels
Evidence indicates that taking Cardarine might really influence the way our blood vessels work.
A study performed on mice revealed it can prohibit oxidative damage that occurs in blood vessels. This is in addition to fostering vessel-relaxing nitric oxide which helps protect blood vessels from the build-up of plaque from the arteries.
In lower doses, Cardarine has been proven to provide tremendous benefits in terms of reducing inflammation and tissue damage. If it can do that, then it might contribute to reducing the risk and complications related to heart disease.
In addition, we understand it has the capability to boost new blood vessel growth in actual human heart cells. This is promising news for heart disease victims but it’s just helpful in limited doses. Cardarine’s ability to increase blood vessels may also be a risk factor for cancer patients.
Lowers the Odds of Bipolar Disorder
According to research done on mice, GW501516 can significantly diminish the occurrence of kidney inflammation which can preclude kidney disease. From the mentioned research, Cardarine managed to slow down the genes linked with kidney disease.
It is Antioxidant
Generally speaking, Cardarine is a powerful inflammation suppressant.
It has been proven to suppress liver inflammation in animals by activating PPAR-delta. It may even suppress inflammation on the DNA level, causing inflammatory enzymes to slow down. In one study, Cardarine was applied topically on mice experiencing diabetic wounds and it greatly accelerated their recovery.
Employing the PPAR-delta pathway, Cardarine managed to suppress inflammation and encourage the survival of the skin tissues in order to improve the skin’s ability to heal the wound. When searching deeper, scientists found that Cardarine can also prevent the creation of inflammatory molecules such as NFκB, IL-6, TNF-alpha, and MCP-1.
It did not stop there, however, since GW501516 stimulated the production of beneficial antioxidant enzymes too.
Protects Liver from harm
This compound mainly concentrates on the liver because it’s a major organ that is responsible for controlling fat at different phases, from burning to preserving and discharging it.
GW501516 can help decrease blood sugar by forcing the liver to derive its energy from fatty acids instead of glucose.
A study done with mice showed that Cardarine may additionally prohibit insulin resistance by reducing the production of IL-6. To establish this point, researchers gave Cardarine into some group of mice that had been consuming a high fructose diet plus it really protected them in liver damage.
Further research revealed that this compound has the power to reduce liver damage in mice by killing degenerative diseases.
POTENTIAL CARDARINE SIDE EFFECTS
In a study with mice that had liver disorder; Cardarine was shown to escalate liver cell death which had the negative effect of actually worsening liver disease.
It was also discovered through animal research that Cardarine is not safe for use during pregnancy because it could inhibit embryonic growth. In rats, it showed the potential to cause cancer. However, the rats were given extremely high doses of Cardarine for longer amounts of time.
The discovery of the dangers led GSK to pause study on this compound even though there’s no evidence to indicate that it might have precisely the identical effect on human subjects.
If you are thinking of taking GW501516 then you need to consider these side effects and the lack of proof so you can make an informed choice in the end.
Bear in mind, it’s only available as a research chemical.
CARDARINE DOSAGE
During clinical studies, researchers used dosages of 2.5 mg to 10 mg every day for 12 months at a time.
Bodybuilders and fitness enthusiasts will use anywhere from 10 to 20mg of Cardarine per day.
A normal SARMs stack which includes GW501516 will continue anywhere from 6 to 10 weeks. These generally include Ostarine and Andarine to help with building muscle.
You’ll also see lots of investigators stack it using SR9009.
CONCLUSION
GW501516 is one of the very widespread compounds from the bodybuilding community. Even athletes turn to the compound to improve their performance and maximize profits.
While we know about GW501516’s ability to increase energy, shred fat and build muscle, the only available study we have is based on animal studies and anecdotal evidence.
Make sure that you purchase GW501516 from a legitimate seller. I highly recommend that you buy SARMs from a reputable source.
My to-go origin is Proven Peptides as they provide the finest quality SARMs.
Therefore, in the event that you decide to use it, then bear this in mind and just take it in the suggested dosages for a brief period of time.
