DMAE Skin & Brain Health Benefits – Dosage & Side Effects

The quests for organic nootropics and anti-aging skincare products intersect with DMAE. It is promoted to improve mood, cognition, and skin wellness — but it might do the opposite instead. We show the science supporting its advantages and side effects, assisting you to determine whether it’s worth an attempt.

What is DMAE?

DMAE (Deanol, 2-dimethylaminoethanol, or dimethylethanolamine) is a chemical that occurs naturally within the mind. Sardines, anchovies, and other fish contain minor amounts of DMAE, but it’s not regarded as a nutritional supplement.

DMAE is a building block for choline and acetylcholine, two elements essential for a healthy brain and nervous system. Doctors used to prescribe it under the trade name Deaner for childhood behavioral issues.

This medication is no longer accessible as a result of questionable efficacy and safety. Regardless of the Deaner ban, DMAE is still a popular nootropic; it is an active ingredient at the cognition-enhancing medication centrophenoxine (Lucidril).

You will also find DMAE in anti-aging and moisturizing skincare products: lotions, serums, and lotions.

What You Should Know About Using DMAE Supplement



  • May enhance mood and cognition
  • May help with attention disorders
  • Enhances skin appearance and hydration


May worsen Alzheimer’s disease and mental disorders
May cause confusion and muscular soreness
Not safe for pregnant women
High amounts may damage skin tissues

DMAE Benefits

How It Works

DMAE may provide antioxidant protection and construct choline, which Is Vital for [4, 5]:

  • Healthy nerves and brain tissues
  • Heart wellness
  • Fat metabolism

As a choline precursor, DMAE might increase acetylcholine (ACh), a neurotransmitter that plays critical roles in cognition and memory.

However, the impact of DMAE on choline and ACh is complex and not yet fully understood. DMAE increases the blood levels of choline, but it also competes for the same mind transporter. As a result, it might not improve acetylcholine in the brain [6].

Two studies on rats discovered no gap in ACh brain levels upon DMAE management.

On the other hand, drugs containing DMAE may stimulate ACh production and cognition. They likely require other chemicals that enhance the uptake and effects of DMAE in the mind.

Possibly Effective:

1) Skin Look

DMAE has gained fame in skincare owing to its assumed anti-aging benefits. The science appears to back up some of those claims with emerging evidence.

Cosmetic gel with 3% DMAE (applied for 4 months) reduced the symptoms of skin aging in a clinical trial of 156 participants. Those who had used the gel reported a rise in:

  • Forehead and eye place coarse wrinkles
  • Lip shape and fullness
  • Dark circles around the eyes
  • Neck hardness
  • Total skin youthfulness

In 30 volunteers, 3% DMAE gel increased facial skin stability.

A formula with DMAE hydrated skin and boosted collagen manufacturing in human areas and mice.

Mesotherapy (skin injections with small needles) using DMAE and amino acids raised the levels of hydration and had remarkable anti-aging consequences in rats.

According to studies on cell cultures and rabbits’ skin, the anti-aging effects of DMAE partly stem from cell damage and skin swelling, which may be a safety concern (additional information in”Side Effects” below).

Insufficient Evidence:

No legitimate clinical evidence supports the use of DMAE for some of the conditions within this section. Below is an overview of up-to-date animal research, cell-based study, or low carb clinical trials that ought to spark a further investigation. However, you shouldn’t interpret them as supportive of any health advantage.

2) Performance and Cognition Enhancement

In a clinical trial of 60 patients having mild mental disorders, Deanol (DMAE) improved cognition, strength, and vitality levels.

A special formulation, DMAE pyroglutamate (1,500 mg/day for 2 days), reversed short-term cognitive impairment in 24 healthy men. Tests on rats revealed the same.

Pyroglutamate itself can boost acetylcholine levels and cognition, and it likely contributed to the outcomes. Additionally, the study on individual subjects lacked a control group.

Centrophenoxine, with DMAE as an active element, boosted long-term memory and improved endurance in 60 healthy elderly subjects. The identical medication improved memory in 50 elderly patients with dementia.

However, DMAE failed to boost cognition in studies on elderly people with mild memory loss and Alzheimer’s disease.

DMAE may have the capability to boost cognition and mental clarity, but clinical evidence is conflicting. Well-designed research should investigate this further.

3) Mental Health

A supplement with DMAEvitamins and nutritional supplements enhanced mood, energy, and wellbeing in a demo of 80 healthy subjects.

Back in 14 senile patients, DMAE (1,800 mg daily for 4 months ) reduced the signals of melancholy, anxiety, and irritability but didn’t benefit cognition. The lack of placebo control and miniature sample prevents us from drawing any conclusion from this research.

Centrophenoxine, which contains DMAE, decreased anxiety in rats exposed to stress. In another study on rats, researchers found its capacity to increase the brain amounts of dopamine and dopamine, which are crucial for good mental health.

On the other hand, DMAE caused unpleasant side effects and worsened mental wellbeing in sensitive individuals. Caution is warranted until we understand more about its psychological health effects.

4) Attention Disorders

Some users claim that DMAE helps with ADHD and other care disorders, but the evidence for that is rare.

Three-month treatment with Deanol (DMAE, 500 mg) improved faculty performance in 74 children with behavior and learning disorders. However, the study had significant drawbacks for example:

  • Little and irregular sample
  • Questionable subject selection
  • Poor symptom dimension

Likely Ineffective:

1) Alzheimer’s Disease

DMAE supplied no significant improvement in two research with over 260 Alzheimer’s disease patients. Some of them even had to stop due to major side effects (more details in”DMAE Side Effects” under).

2) Movement Disorders

There is no proof to back up the anecdotal benefits of DMAE for movement disorders.

Clinical trials have found no significant improvement in tardive dyskinesia, chorea, and other movement disorders.

DMAE Side Effects

This listing doesn’t cover all possible side effects. Speak to your doctor or pharmacist if you see any side effects. In the united states, you may report side effects to the FDA at 1-800-FDA-1088 or at In Canada, you may report side effects to Health Canada in 1-866-234-2345.

DMAE is possibly safe for oral and topical programs when used in appropriate amounts in healthy people.

However, the oral application might cause substantial side effects on mental health in vulnerable individuals. Based on case reports, higher doses of DMAE may lead to insomnia, muscle cramps, and twitches.

Mental Health and Cognition

DMAE worsened the symptoms of depression, bipolar disorder, and schizophrenia in some patients with psychological illnesses.

In one clinical trial using Alzheimer’s disease sufferers, 6 from 13 subjects had to stop due to drowsiness and cognitive disturbance.


Pregnant women should avoid DMAE because it may cause birth defects. It impaired choline metabolism in mouse embryos, which led to birth defects and growth retardation.


Skincare of gels and creams with DMAE did not induce irritation or other side effects in clinical trials.

However, 3% DMAE gel brought on swelling of their bunny’s ear skin, indicating cell harm. In a different study, higher DMAE concentrations (around 10%) inhibited the growth of human skin tissues as well as shortened their life span.

Given the above benefits, you might choose to go slow with DMAE to your skin and prevent concentrated serums.

Medication Interactions

Supplement-drug interactions can be harmful and, in rare circumstances, even life-threatening. Always ask your doctor before supplementing and let him know about all medications and supplements you are using or considering.

DMAE may increase the levels of acetylcholine and hinder its brain transport. Therefore, It may interact with two Big drug classes:

  • Cholinergic, used mainly for Alzheimer’s disease
  • Anticholinergics, used for Parkinson’s disease, COPD, and overactive bladder

DMAE Supplements & Dosage

DMAE supplements have not been accepted by the FDA for medical use. In general, regulatory bodies aren’t promising the quality, safety, and efficacy of nutritional supplements. Speak with your physician before supplementing.

Capsulated DMAE bitartrate (130 — 250 mg pure DMAE) is the most popular supplement type, followed by bulk powders.

For those aiming in skincare, different DMAE creams and anti-age serums are available. The majority of them also include coenzyme Q10, vitamin C, MSM, vitamin E, along with other beneficial ingredients. In clinical trials, 3% DMAE gel improved skin appearance, utilized daily for 4 months.


The below doses may not apply to you. If your doctor suggests utilizing DMAE, work together to locate the optimal dose in accordance with your health condition and other factors.

The following DMAE dose was effective in clinical trials:

Cognitive impairment

  • Short-term: 1,500 mg daily for 6 days
  • In mental disorders: 1,000 milligrams daily for 1 month

The mood in senile patients: 600 mg, 3X daily for 1 month
Attention disorders in kids: 500 mg daily for 3 months

User Reviews

The opinions expressed in this section are solely in the users that might or might not have a medical background. Their reviews don’t reflect the opinions of SelfHacked. SelfHacked doesn’t endorse any particular product, service, or treatment.

Do not believe user experiences as medical advice. Never delay or disregard seeking professional medical advice from your doctor or another professional health care provider because of something you’ve read on SelfHacked.

People today report favorable outcomes with DMAE for memory, mental clarity, and energy. Some parents have managed to control their children’s symptoms of ADHD and other eye ailments.

Consumers are warning about sleep issues and overtraining in higher doses. Other reported side effects include nausea, headaches, and worsened mood disorders (irritability, depression).

Most users have confirmed the anti-aging skin advantages of DMAE for both cosmetics and pills. Some of them add it to homemade lotions and face masks. Skin irritation and unpleasant odor are the most common complaints.


DMAE occurs naturally within the body, in which it creates choline and acetylcholine. Seafood includes small amounts, while supplements may provide considerably more.

Many nootropic products contain DMAE, but there’s insufficient evidence to back up its purported advantages for mood, cognition, and attention disorders.

Skincare products with DMAE can tighten skin and give it a more youthful look. Use them in moderation and avoid highly concentrated serums — they might cause skin irritation.

Prevent DMAE should you have mental health issues or Alzheimer’s because it may worsen the symptoms. Pregnant women must also skip it, though some need to consult their doctor first.